Born in Berlin, Helene Schweitzer came of age in Strasbourg during a time of great social, architectural, and historical developments. It was in this cultural milieu, as a history professor’s daughter, that Helene met a young pastor named Albert Schweitzer (1875–1965) and developed a deep friendship that flourished for a decade before their marriage in 1912. During those years, she served as the first woman Inspector of City Orphanages in Strasbourg, a position she held for four years before becoming a certified nurse. She also edited and proofread a number of Schweitzer’s books in multiple fields as they worked together to realize their shared dream of devoting their lives tohumanity. Together in 1913, Albert and Helene Schweitzer founded what is now the longest-running hospital established by Europeans in Africa, the Albert Schweitzer Hospital in current-day Gabon. With her quiet strength, clear sense of purpose, independent spirit, and wide range of skills and talents, Helene was a model for many other women who later served the Schweitzer Hospital. Drawing upon the couple’s lifelong correspondence, as well as Helene’s journals and professional writing, Marxsenreveals a modern woman of courage in dark times whose resilient, optimistic spirit allowed her to leave a lasting legacy that has yet to be fully understood. Helene Schweitzer’s dramatic life reveals deeper questions of how memory is influenced by gender assumptions and how biography is shaped by place and history. By providing a counter-narrative to the traditional image of a frail woman who sacrificed her life to her husband’s genius, this richly detailed chronicle of a little-known figure invites a larger discussion about the meaning of a woman’s life obscured by a partner’s fame.