The existence of health inequities across racial, ethnic, gender, and class lines in the United States has been well documented. Less well understood have been the attempts of major institutions, health programs, and other public policy domains to eliminate these inequities. This issue, a collaboration with the Robert Wood Johnson Foundation Investigator Awards in Health Policy Research Program, brings together respected historians, political scientists, economists, sociologists, and legal scholars to focus on the politics and challenges of achieving health equity in the United States. Articles in this issue address the historical, legal, and political contexts of health equity in the United States. Contributors examine the role of the courts in shaping health equity; document the importance of political discourse in framing health equity and establishing agendas for action; look closely at particular policies to reveal current challenges and the potential to achieve health equity in the future; and examine policies in both health and nonhealth domains, including state Medicaid programs, the use of mobile technology, and education and immigration policies. The issue concludes with a commentary on the future of health equity under the Trump administration and an analysis of how an ACA repeal would impact health equity. Contributors. Alan B. Cohen, Keon L. Gilbert, Daniel Q. Gillion, Colleen M. Grogan, Mark A. Hall, Jedediah N. Horwitt, Tiffany D. Joseph, Alana M.W. LeBron, Julia F. Lynch, Jamila D. Michener, Vanessa Cruz Nichols, Francisco Pedraza, Isabel M. Perera, Rashawn Ray, Jennifer D. Roberts, Sara Rosenbaum, Sara Schmucker, Abigail A. Sewell, Deborah Stone, Keith Wailoo