The 531 revised full papers presented were carefully reviewed and selected from 1630 submissions in a double-blind review process. The papers are organized in the following topical sections:

Part I: image segmentation

Part II: machine learning - self-supervised learning; machine learning - semi-supervised learning; and machine learning - weakly supervised learning

Part III: machine learning - advances in machine learning theory; machine learning - attention models; machine learning - domain adaptation; machine learning - federated learning; machine learning - interpretability / explainability; and machine learning - uncertainty

Part IV: image registration; image-guided interventions and surgery; surgical data science; surgical planning and simulation; surgical skill and work flow analysis; and surgical visualization and mixed, augmented and virtual reality

Part V: computer aided diagnosis; integration of imaging with non-imaging biomarkers; and outcome/disease prediction

Part VI: image reconstruction; clinical applications - cardiac; and clinical applications - vascular

Part VII: clinical applications - abdomen; clinical applications - breast; clinical applications - dermatology; clinical applications - fetal imaging; clinical applications - lung; clinical applications - neuroimaging - brain development; clinical applications - neuroimaging - DWI and tractography; clinical applications - neuroimaging - functional brain networks; clinical applications - neuroimaging - others; and clinical applications - oncology

Part VIII: clinical applications - ophthalmology; computational (integrative) pathology; modalities - microscopy; modalities - histopathology; and modalities - ultrasound

*The conference was held virtually.